Synthetic gene circuits enable systems-level biosensor discovery at the host-microbe interface
Alexander D. Naydich, Shannon N. Nangle, Johannes Bues, Disha Trivedi, Nabeel Nissar, Mara C. Inniss, Matthew J. Niederhuber, Jeffrey C. Way, Pamela A. Silver, David T. Riglar
The paper develops a synthetic gene circuit system to identify in vivo-responsive biosensors in gut bacteria, demonstrating their utility in both healthy and inflamed gut environments.
mSystems · Jun 10, 2019Peer-reviewedSynthetic Biology