Jeffrey C. Way

An Fc-SPINK1 fusion protein inhibits pancreatic inflammation in a mouse model

This paper develops an Fc-SPINK1 fusion protein that reduces pancreatic inflammation in mice by extending its half-life and inhibiting trypsin activity.

Rational design of selective bispecific EPO-R/CD131 agonists

The paper designs bispecific agonists targeting EPO-R/CD131 to selectively activate signaling without engaging EPO-R/EPO-R, validated through structural modeling and functional assays.

Tardigrade secretory proteins protect biological structures from desiccation

This study investigates SAHS proteins from tardigrades, showing they protect biological structures from desiccation by preventing liposome fusion and enhancing microbial survival.

A long-acting prolactin to combat lactation insufficiency

This paper engineers a long-acting prolactin variant to enhance lactation, showing it increases milk production and restores pup growth in mice.

High content screening and computational prediction reveal viral genes that suppress innate immune response

The paper develops a high-content assay to identify viral genes that suppress innate immunity and validates known and novel immune suppressors from various viral families.

Natural and designed proteins inspired by extremotolerant organisms can form condensates and attenuate apoptosis in human cells

The paper identifies extremotolerant proteins that form condensates and protect human cells from apoptosis, including a synthetic protein and a region of ApoE.

High-content screening of coronavirus genes for innate immune suppression revealsenhanced potency of SARS-CoV-2 proteins

The paper screens coronavirus proteins for innate immune suppression, finding SARS-CoV-2 proteins are more potent immune suppressors than other coronaviruses.

Rational engineering of an erythropoietin fusion protein to treat hypoxia

This paper describes the design of a modified erythropoietin fusion protein that promotes red blood cell production and neuroprotection without causing thrombosis.

Synthetic cassettes for pH-mediated sensing, counting and containment

The paper develops a pH-sensitive kill switch and pulse-counting circuit for bacterial containment and sensing.

Stable neutralization of virulent bacteria using temperate phage in the mammalian gut

The paper uses engineered bacteriophage to reduce shigatoxin production in an enteric mouse model by targeting virulent bacteria without significantly affecting bacterial concentrations.

Rational Design of a Bifunctional AND-Gate Ligand to Modulate Cell-Cell Interactions

The paper designs a bifunctional AND-gate ligand to modulate cell-cell interactions by avoiding thrombosis and RBC adhesion.

Engineered inter-species amino acid cross-feeding increases population evenness in a synthetic bacterial consortium

The paper engineers inter-species amino acid cross-feeding in bacterial consortia to increase population evenness in synthetic microbial communities.

Synthetic gene circuits enable systems-level biosensor discovery at the host-microbe interface

The paper develops a synthetic gene circuit system to identify in vivo-responsive biosensors in gut bacteria, demonstrating their utility in both healthy and inflamed gut environments.

A synthetic bacterial information transfer system functions in the mammalian gut

The paper engineers a synthetic bacterial communication system in the mammalian gut using quorum sensing and bacteriophage genetic switch circuits.

Mammalian Cells Engineered to Produce Novel Steroids

The paper demonstrates that mammalian cells can produce novel steroids using steroid-modifying enzymes, identifying new hydroxylation sites and potential applications for drug candidate testing.

Rational Design of Evolutionarily Stable Microbial Kill Switches

This paper designs and tests two evolutionarily stable kill switches in E. coli, showing they maintain functionality for over 140 generations in vitro and limit escape in vivo.

Rapid genome recoding by iterative recombineering of synthetic DNA

This paper introduces a method for rapid genome recoding in Salmonella typhimurium by iteratively recombineering synthetic DNA, achieving the highest number of codon substitutions in a single organism.

Engineering Genetically-Encoded Mineralization and Magnetism via Directed Evolution

The paper engineers genetically-encoded magnetism and mineralization by mutating ferritin and characterizing DUF892 family proteins in E. coli.