Author

Alexander D. Naydich

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Assay:proteomics· 1

Frequent Co-Authors

Pamela A. SilveriD· 3 shared David T. RiglariD· 2 shared Jeffrey C. WayiD· 2 shared Adam Cusolito· 1 shared Andrew A VerdegaaliD· 1 shared David RichmondiD· 1 shared Disha TrivediiD· 1 shared Elizabeth S. P. Redfield· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersSynthetic Biology

Pamela A. SilverORCID

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3 papers

Recent·Most cited

Synthetic cassettes for pH-mediated sensing, counting and containment

Finn Stirling, Alexander D. Naydich, Juliet Tongue Bramante, Rachel Barocio, Michael V. Certo, Hannah Wellington, Elizabeth S. P. Redfield, Samuel O’Keefe, Xue Gao, Adam Cusolito, Jeffrey C. Way, Pamela A. Silver

The paper develops a pH-sensitive kill switch and pulse-counting circuit for bacterial containment and sensing.

Cell Reports · Mar 1, 2020Peer-reviewedSynthetic Biology

Variability of bacterial behavior in the mammalian gut captured using a growth-linked single-cell synthetic gene oscillator

David T. Riglar, David Richmond, Laurent Potvin-Trottier, Andrew A Verdegaal, Alexander D. Naydich, Somenath Bakshi, Emanuele Leoncini, Lorena G. Lyon, Johan Paulsson, Pamela A. Silver

This study uses a synthetic gene oscillator to analyze bacterial growth dynamics in the gut under healthy and inflammatory conditions, revealing variability in single-cell behavior.

Nature Communications · Oct 11, 2019Peer-reviewedSynthetic Biology

Synthetic gene circuits enable systems-level biosensor discovery at the host-microbe interface

Alexander D. Naydich, Shannon N. Nangle, Johannes Bues, Disha Trivedi, Nabeel Nissar, Mara C. Inniss, Matthew J. Niederhuber, Jeffrey C. Way, Pamela A. Silver, David T. Riglar

The paper develops a synthetic gene circuit system to identify in vivo-responsive biosensors in gut bacteria, demonstrating their utility in both healthy and inflamed gut environments.

mSystems · Jun 10, 2019Peer-reviewedSynthetic Biology