Matthew J. Niederhuber

This study shows that integrin α3β1 is essential for alveolar-capillary barrier formation by regulating epithelial differentiation during lung development.

This study identifies dithiocarbamates as chemicals that disrupt TDP-43 proteostasis by causing aggregation and loss of function through redox imbalance and zinc homeostasis disruption.

This study shows that the Drosophila BAP complex, a SWI/SNF remodeler, constrains enhancer activity during wing development, preventing ectopic sensory structures and hyperactivation of the Delta gene.

This study shows that the transcription factor E93 regulates enhancer activity and chromatin accessibility during Drosophila wing development, accelerating the developmental program by altering enhancer competence.

The paper develops a synthetic gene circuit system to identify in vivo-responsive biosensors in gut bacteria, demonstrating their utility in both healthy and inflamed gut environments.