BiophysicsbioRxivPreprint
Pathological stiffening by crosslinking glycation of titin
Agata Bak, Andra C. Dumitru, Alejandro Clemente-Manteca…·Jorge Alegre‐Cebollada
This study shows that glycation of cardiac titin increases in diabetes, leading to protein and cardiomyocyte stiffening through crosslinking advanced glycation end products.
DOI 10.64898/2026.02.13.705744