Andra C. Dumitru

This study shows that methylglyoxal-derived glycation increases nuclear stiffness and alters mechanosensitive signaling in cells and tissues.

This study shows that inducing sarcomere disassembly in cardiomyocytes via titin cleavage does not lead to cell proliferation, suggesting additional factors are needed for cardiomyocyte division.

This study shows that glycation of cardiac titin increases in diabetes, leading to protein and cardiomyocyte stiffening through crosslinking advanced glycation end products.