Author

Alejandro Clemente-Manteca

Spanish National Centre for Cardiovascular ResearchORCID 0000-0001-9385-4897Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

David Sánchez-OrtiziD· 2 shared Diana Velázquez-CarrerasiD· 2 shared Elías Herrero‐GalániD· 2 shared Jorge Alegre‐CebolladaiD· 2 shared María Rosaria PricoloiD· 2 shared Natalia Vicente· 2 shared Roberto Silva‐RojasiD· 2 shared Agata BakiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersBiophysics

David Sánchez-OrtizORCID

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2 papers

Recent·Most cited

Pathological stiffening by crosslinking glycation of titin

Agata Bak, Andra C. Dumitru, Alejandro Clemente-Manteca, Enrique Calvo, Roberto Silva‐Rojas, Natalia Vicente, David Sánchez-Ortiz, Inés Martínez-Martín, Diana Velázquez-Carreras, María Rosaria Pricolo, Francisco M. Espinosa, João Almeida‐Coelho, Carlos Pérez‐Medina, Ricardo Alexandrino Garcia, Jesús Vázquez, , Jorge Alegre‐Cebollada

This study shows that glycation of cardiac titin increases in diabetes, leading to protein and cardiomyocyte stiffening through crosslinking advanced glycation end products.

bioRxiv · Feb 14, 2026 · PreprintBiophysics

Titin cleavage is a driver of cardiomyocyte disengagement and reactive myocardial fibrosis

Miguel Ángel López-Unzu, María Rosaria Pricolo, Roberto Silva‐Rojas, Alejandro Clemente-Manteca, David Sánchez-Ortiz, Natalia Vicente, Diana Velázquez-Carreras, Cristina Morales, Manuel Gavilán-Herrera, Laura Sen-Martín, Ángel Fernández‐Trasancos, Verónica Labrador-Cantarero, Lucía Sánchez-García, Carlos Relaño‐Rupérez, Fátima Sánchez‐Cabo, , Jorge Alegre‐Cebollada

This study shows that titin cleavage drives cardiomyocyte disengagement and fibrosis in heart disease, contributing to myocardial remodeling.

bioRxiv · Apr 22, 2025 · PreprintPhysiology