Rupert Faraway

The paper identifies a homeostatic mechanism called interstasis that co-regulates the dosage of proteins with low complexity domains through RNA-based negative feedback.

The paper identifies 3UTR-derived capped RNAs, showing they are abundant and originate from AGO2-mediated cleavage at G-quadruplexes, with implications for APP protein regulation.

The paper introduces hamFISH, a method for multiplexed in situ hybridization to profile gene expression, connectivity, and activity in the medial amygdala of mice, identifying 16 inhibitory and 10 excitatory neuron types.

Flow provides a web platform and database for managing and analyzing large-scale bioinformatics data, addressing challenges in data processing, quality, and accessibility.

The paper identifies LIN28A as a key factor in mRNA decay during epiblast morphogenesis, linking cell identity changes to embryonic growth through nucleo-cytoplasmic translocation.

The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.

The paper uses spliceosome iCLIP to map human spliceosome engagement with snRNAs and pre-mRNAs, identifying over 50,000 branchpoints and their associated splicing factor binding patterns.

This paper introduces a mathematical framework to improve Mendelian randomization analysis for drug targets by addressing horizontal pleiotropy when proteins are the risk factors.