Author

Mischa Machius

The University of Texas Medical Branch at GalvestonORCID 0000-0002-6040-1362Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alfred Jay RobisoniD· 2 shared Anil KumariD· 2 shared Ashwani KumariD· 2 shared Brandon W. HughesiD· 2 shared Corey P. St. RomainiD· 2 shared Earnest P. CheniD· 2 shared Eric J. NestleriD· 2 shared Gabby RudenkoiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Alfred Jay RobisonORCID

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2 papers

Recent·Most cited

NeuroscienceJournal of Biological ChemistryPeer-reviewedDec 22, 2025

Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor DeltaFOSB

Sean McNeme, Yun Young Yim, Ashwani Kumar…·Gabby Rudenko

The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.

4 citations

humanChIP-seq

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NeurosciencebioRxivPreprintOct 21, 2025

Efficient in vivo pharmacological inhibition of deltaFOSB, an AP1 transcription factor, in brain

Sean McNeme, Anil Kumar, Yun Young Yim…·Gabby Rudenko

This paper demonstrates the creation of YL0441, a highly effective inhibitor of DeltaFOSB that reduces genomic DNA binding sites by ~94% in APP mice.

DOI 10.1101/2025.10.21.683721

mouseexperimental assay

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