Yun Young Yim

The paper identifies synaptic bioenergetic remodeling in the mPFC after heroin abstinence, but not cocaine, and links it to relapse vulnerability.

The paper identifies a shared transcriptional network in the nucleus accumbens that supports stress resilience in both sexes and shows causal effects of hub genes.

The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.

This paper demonstrates the creation of YL0441, a highly effective inhibitor of DeltaFOSB that reduces genomic DNA binding sites by ~94% in APP mice.

The paper investigates cocaine-induced astrocyte-specific transcriptome in mice, identifies CREB as a key regulator, and shows its role in modulating neuronal and behavioral responses to cocaine.

This study shows that adolescent HIIT in rats reduces cocaine place preference and increases striatum ΔFosB, suggesting potential protective effects against cocaine abuse.

This study shows that E2F3a overexpression in D1-MSNs increases cocaine reward in both male and female mice, while knockdown has opposite effects, with no impact in D2-MSNs.

This study shows that disrupting Gβγ-SNARE interaction in mice leads to impaired gait, nociception, and hippocampal function, highlighting its role in GPCR-mediated presynaptic inhibition.