Direct serological antibody discovery by integrative proteomics yields potent neutralizers overlooked by single-cell BCR sequencing
Sem Tamara, Danique M.H. van Rijswijck, Jacqueline van Rijswijk, Judith A. Burger, Douwe Schulte, Marta Moreschini, Godelieve J. de Bree, Marit J. van Gils, Albert J. R. Heck, Maurits A. den Boer
The paper introduces AbDirect, a proteomics-based method for antibody discovery that identifies potent neutralizing antibodies missed by single-cell BCR sequencing in COVID-19 plasma.
bioRxiv · May 20, 2026 · PreprintImmunology