Author

Danique M.H. van Rijswijck

Utrecht UniversityORCID 0000-0003-1377-9992Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Albert J. R. HeckiD· 3 shared Athanasios SmyrnakisiD· 1 shared Bart EvertsiD· 1 shared Corrie M. WorteliD· 1 shared Cynthia M. FehresiD· 1 shared de Vries-Bouwstra Jk· 1 shared Detlev SuckauiD· 1 shared Dimitris K PapanastasiouiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

Albert J. R. HeckORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 20, 2026

Direct serological antibody discovery by integrative proteomics yields potent neutralizers overlooked by single-cell BCR sequencing

Sem Tamara, Danique M.H. van Rijswijck, Jacqueline van Rijswijk…·Maurits A. den Boer

The paper introduces AbDirect, a proteomics-based method for antibody discovery that identifies potent neutralizing antibodies missed by single-cell BCR sequencing in COVID-19 plasma.

DOI 10.64898/2026.05.20.725438

humanproteomics

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ImmunologyAnnals of the Rheumatic DiseasesPeer-reviewedApr 12, 2026

Enhanced recognition of topoisomerase 1 upon DNA binding by a subset of anti-topoisomerase 1 autoantibodies in systemic sclerosis

Sam Neppelenbroek, Corrie M. Wortel, Danique M.H. van Rijswijck…·Hans Ulrich Scherer

This study shows that some anti-topoisomerase 1 autoantibodies (ATAs) in systemic sclerosis (SSc) bind more strongly to TOP1-DNA cleavage complexes, correlating with disease severity and immune activation.

1 citation

humanproteomics

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BiochemistrybioRxivPreprintOct 29, 2025

A prototype timsOmni platform enables confident annotation of key hypervariable regions of IgG immunoglobulins using low- and high-energy electron-based fragmentation.

Simon Ollivier, Dina Schuster, Danique M.H. van Rijswijck…·Albert J. R. Heck

1 citation

proteomicsexperimental assay

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