Douwe Schulte

borgonovo improves protein sequence accuracy from tandem mass spectra by consensus assembly of redundant de novo peptide reads, achieving 0.87 mean fixed-window identity on therapeutic antibodies.

The paper introduces AbDirect, a proteomics-based method for antibody discovery that identifies potent neutralizing antibodies missed by single-cell BCR sequencing in COVID-19 plasma.

The paper introduces a universal tool for annotating peptide spectra in proteomics, supporting various fragmentation methods and modifications.

This study determines the epitope of the postfusion-specific antibody 131-2a against RSV-F using mass spectrometry, revealing the structural basis for its specificity.

This paper introduces HTA-proteases for de novo antibody sequencing, achieving higher peptide read coverage and accuracy compared to trypsin or chymotrypsin.

The paper evaluates the Orbitrap Astral mass spectrometer for plasma glycoproteome analysis, introducing nGlycoDIA to achieve high sensitivity and throughput.

The paper evaluates using cryoEM and mass spectrometry with a deep-learning tool to sequence antibodies and map epitopes from convalescent serum, showing 80-90% accuracy in variable domain sequencing.

The paper improves the accuracy of antibody sequence reconstruction from bottom-up proteomics data by addressing mass coincidence errors in de novo sequencing.

The paper introduces Stitch, a software tool for mapping proteomic short reads to templates to sequence monoclonal and profile polyclonal antibodies with high accuracy.