Author

Zhuobin Lin

State Key Laboratory of OphthalmologyORCID 0000-0002-6076-5879Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:Hi-C· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Chuan‐Le XiaoiD· 3 shared Longjian NiuiD· 3 shared Chunhui HouiD· 2 shared Feng LuoiD· 2 shared Jiayong ZhongiD· 2 shared Ying CheniD· 2 shared Bo Ming WuiD· 1 shared Bo WuiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBioinformatics

Chuan‐Le XiaoORCID

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3 papers

Recent·Most cited

High accuracy methylation identification tools on single molecular level for PacBio HiFi data

Ying Chen, Bo Wu, Yuying Ding, Longjian Niu, Xin Lai Bai, Zhuobin Lin, Chuan‐Le Xiao

The paper introduces hifimeth, a deep learning model that improves 5mC detection accuracy on PacBio HiFi data by using 400 bp context, achieving higher accuracy and F1 score than existing methods.

bioRxiv · Aug 14, 2024 · PreprintBioinformatics

High-resolution diploid 3D genome reconstruction using Pore-C data

Ying Chen, Zhuobin Lin, Shaokai Wang, Bo Ming Wu, Longjian Niu, Jiayong Zhong, Yimeng Sun, Xin Bai, Luo-Ran Liu, Wei Xie, Ruibang Luo, Chunhui Hou, Feng Luo, Chuan‐Le Xiao

This paper introduces Dip3D, a method to reconstruct high-resolution diploid 3D human genomes from Pore-C data, achieving better performance than existing methods.

bioRxiv · Aug 29, 2023 · PreprintGenomics

Falign: An effective alignment tool for long noisy 3C data

Ying Chen, Zhuobin Lin, Longjian Niu, Jiayong Zhong, Yizhi Liu, Chunhui Hou, Feng Luo, Chuan‐Le Xiao

Falign improves alignment of fragmented long noisy 3C data by addressing fragment boundary issues and increasing data utilization.

bioRxiv · Oct 30, 2022 · PreprintBioinformatics