Cell BiologyNature NeurosciencePeer-reviewed
Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease
Xiuli Dan, Deborah L. Croteau, Wenlong Liu…·Vilhelm A. Bohr
The paper identifies mitochondrial plaques in Alzheimer's disease by showing their presence in AD mouse models and human brains, linking them to mitophagy dysfunction and lysosomal impairment.