Author

Xixia Chu

National Institute on Aging

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Deborah L. CroteauiD· 2 shared Vilhelm A. BohriD· 2 shared Beimeng Yang· 1 shared Bergithe E. Oftedal· 1 shared Bing ZhangiD· 1 shared Chaochun WeiiD· 1 shared Christopher N. Hahn· 1 shared David L. AdelsoniD· 1 shared

Activity by Year

2015-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Deborah L. CroteauORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease

Xiuli Dan, Deborah L. Croteau, Wenlong Liu, Xixia Chu, Ross A. McDevitt, Paul D. Robbins, Vilhelm A. Bohr

The paper identifies mitochondrial plaques in Alzheimer's disease by showing their presence in AD mouse models and human brains, linking them to mitophagy dysfunction and lysosomal impairment.

Nature Neuroscience · Jul 29, 2026Peer-reviewedCell Biology

Urolithin A improves Alzheimers disease cognition and restores mitophagy and lysosomal functions

Yujun Hou, Xixia Chu, Jae Hyeon Park, Qing Zhu, Mansoor Hussain, Zhiquan Li, Helena Borland Madsen, Beimeng Yang, Yong Quek Wei, Yue Wang, Evandro Fei Fang, Deborah L. Croteau, Vilhelm A. Bohr

This study shows that Urolithin A improves cognitive function and restores mitophagy and lysosomal functions in Alzheimer's disease mouse models.

Alzheimer s & Dementia · May 16, 2024Peer-reviewedNeuroscience

Revealing missing isoforms encoded in the human genome by integrating genomic, transcriptomic and proteomic data

Zhiqiang Hu, Hamish S. Scott, Guangrong Qin, Guangyong Zheng, Xixia Chu, Lu Xie, David L. Adelson, Bergithe E. Oftedal, Parvalthy Venugopal, Milena Barbic, Christopher N. Hahn, Bing Zhang, Xiaojing Wang, Nan Li, Chaochun Wei

The paper identifies 31,566 novel protein-coding transcripts and estimates the total human protein-coding transcripts to be over 200,000 by integrating genomic, transcriptomic, and proteomic data.

Scientific Reports · Jul 9, 2015Peer-reviewedGenomics