Author

Maxime J. Derisbourg

Max Planck Institute for Biology of AgeingORCID 0000-0002-9293-1413Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Laura E. WesteriD· 2 shared Martin Sebastian DenzeliD· 2 shared Bérénice Anath BenayouniD· 1 shared Charlotte LalouxiD· 1 shared Claire RegostiD· 1 shared Coline Leghay· 1 shared David L BlumiD· 1 shared Felix A.M.C. MayriD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenetics

Laura E. WesterORCID

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Author profile →

3 papers

Recent·Most cited

N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer Disease

Sarah Guedjdal, Coline Leghay, Maxime J. Derisbourg, Sabiha Eddarkaoui, Simon Lecerf, Florian Vermon, Raphaëlle Caillierez, Séverine Bégard, Claire Regost, Charlotte Laloux, Paulo J. da Costa, Kévin Carvalho, Giovanni Chiappetta, Yann Verdier, Valérie Buée‐Scherrer, , Malika Hamdane

This study identifies and characterizes a novel N-terminally acetylated Tau variant that accumulates in AD models and patients, exacerbates pathology, and is a potential therapeutic target.

Translational Neurodegeneration · Apr 27, 2026Peer-reviewedNeuroscience

NHR-8 regulated P-glycoproteins uncouple xenobiotic stress resistance from longevity in chemosensory C. elegans mutants

Gabriel A Guerrero, Maxime J. Derisbourg, Laura E. Wester, Marco Gordia, J Eike Dinort, María J. Alonso, Matías Daniel Hartman, Klara Schilling, Felix A.M.C. Mayr, Ryan J. Lu, Bérénice Anath Benayoun, Martin Sebastian Denzel

The paper identifies that NHR-8 regulates P-glycoproteins in C. elegans, uncoupling xenobiotic stress resistance from longevity in osm-3 mutants.

eLife · Aug 27, 2021Peer-reviewedGenetics

eIF2B extends lifespan through inhibition of the integrated stress response

Maxime J. Derisbourg, Laura E. Wester, Ruth Baddi, Martin Sebastian Denzel

This study identifies eIF2B's role in extending lifespan by inhibiting the integrated stress response in C. elegans, improving protein homeostasis without altering overall protein synthesis.

Nature Communications · Mar 15, 2021Peer-reviewedGenetics