Emilia M. Lefevre

The paper identifies nucleus accumbens inhibitory interneurons as a key site where mu opioid receptor expression promotes social behavior, distinct from its role in exogenous opioid sensitivity.

This study compares synaptic plasticity in the nucleus accumbens under continuous vs interrupted morphine exposure in mice, finding divergent effects on inhibitory synapses and D1-MSN output.

This study shows that partial reduction of mu opioid receptor signaling in mice leads to social behavior deficits and changes in nucleus accumbens microcircuitry.

This study shows that interrupting continuous opioid exposure increases drug-evoked adaptations in the mesolimbic dopamine system, leading to greater behavioral and transcriptional changes.

This study shows that fast-spiking interneurons in the nucleus accumbens reduce impulsive actions in mice by inhibiting medium spiny neurons through GABA signaling.