Interruption of Continuous Opioid Exposure Exacerbates Drug-Evoked Adaptations in the Mesolimbic Dopamine System
Emilia M. Lefevre, Marc T. Pisansky, Carlee Toddes, Federico Baruffaldi, Marco Pravetoni, Lin Tian, Thomas J. Y. Kono, Patrick E. Rothwell
This study shows that interrupting continuous opioid exposure increases drug-evoked adaptations in the mesolimbic dopamine system, leading to greater behavioral and transcriptional changes.
Neuropsychopharmacology · Feb 20, 2020Peer-reviewedNeuroscience