Valentín Iglesias

The paper proposes that PfAP2 transcription factors in Plasmodium falciparum use liquid-liquid phase separation (LLPS) to sense environmental changes and regulate gene responses, suggesting LLPS as a therapeutic target.

The paper introduces two web servers, SolupHred and DispHred, to predict pH-dependent aggregation and disorder in intrinsically disordered proteins.

This paper updates A3D to predict and optimize protein solubility using a computational pipeline and RESTful service for handling large protein collections.

The paper evaluates 43 methods for predicting intrinsically disordered regions and binding regions in proteins, finding that deep learning methods outperform older physicochemical approaches but binding prediction remains challenging.