Yunuen Avalos‐Padilla

The paper proposes that PfAP2 transcription factors in Plasmodium falciparum use liquid-liquid phase separation (LLPS) to sense environmental changes and regulate gene responses, suggesting LLPS as a therapeutic target.

This study shows that disrupting the hexosamine biosynthetic pathway in Plasmodium falciparum blocks GPI production, arrests parasite growth, and prevents egress from host cells.