Author

Elizabeth M. Brydon

Massachusetts Eye and Ear InfirmaryORCID 0000-0002-6140-8005Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

Adriana BuskiniD· 1 shared Anant Chopra· 1 shared Christina V. TheodorisiD· 1 shared Clement Y. ChowiD· 1 shared Eric A. PierceiD· 1 shared Hans M. DaltoniD· 1 shared Helene Mantineo· 1 shared Katie G OwingsiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperNeuroscience

Adriana BuskinORCID

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3 papers

Recent·Most cited

GeneticsHuman Genetics and Genomics AdvancesPeer-reviewedAug 27, 2026

The stress-induced transcription factor ATF4 has multiple conserved retrocopies that can alter gene expression

Hans M. Dalton, Elizabeth M. Brydon, Tiffany S. Chan…·Clement Y. Chow

This study identifies and characterizes conserved ATF4 retrocopies in primates that are functionally active and influence ISR signaling.

DOI 10.1016/j.xhgg.2026.100666

humannon-human primate

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BioinformaticsNaturePeer-reviewedMay 31, 2023

Transfer learning enables predictions in network biology

Christina V. Theodoris, Ling Xiao, Anant Chopra…·Patrick T. Ellinor

The paper applies transfer learning to predict network biology features across different biological contexts.

1,193 citationstop 1%

machine learning (classical)

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NeuroscienceMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewedNov 11, 2019

AAV-mediated gene augmentation therapy restores critical functions in mutant iPSC-derived PRPF31+/- cells.

Elizabeth M. Brydon, Revital Bronstein, Adriana Buskin…·Rosario Fernández‐Godino

This study shows that AAV-mediated gene augmentation therapy can restore critical functions in PRPF31 mutant iPSC-derived RPE cells, providing proof-of-concept for treating PRPF31-related retinitis pigmentosa.

56 citations

humanexperimental assay

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