Brendan William Wren

This paper develops a dual-target glycoconjugate vaccine against Shigella sonnei using a carrier protein and O-antigen, showing it elicits IgG responses to both components.

This study identifies two novel T6SS effectors in C. jejuni and shows their role in bacterial antagonism and host cell interaction.

This study re-evaluates chemotaxis in Acanthamoeba species using advanced imaging and tracking, revealing species-specific responses to chemoattractants and suggesting receptor threshold tuning for niche adaptation.

This study shows that Campylobacter jejuni activates the unfolded protein response (UPR) in human intestinal epithelial cells, which contributes to inflammation and pathogenesis.

This paper detects lysine lactylation in Campylobacter using an antibody, showing strain-specific and lactate-responsive modifications.

This study investigates how Campylobacter jejuni interacts with Acanthamoeba castellanii, revealing metabolic and genetic changes in the amoeba that may aid bacterial survival.

This study develops a platform for recombinant production of Group A Streptococcus glycoconjugate vaccines using E. coli, confirming their structural integrity and immunogenicity in animal models.

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.