Molecular BiologybioRxivPreprint
Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, eIF2B
Alisa F. Zyryanova, Félix Weis, Alexandre Faille…·David Ron
The paper identifies an ISRIB-binding site in eIF2B using cryo-EM and CRISPR/Cas9, showing its role in regulating translation through an allosteric mechanism.
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