Author

Ana Crespillo-Casado

MRC Laboratory of Molecular BiologyORCID 0000-0002-7230-3188Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 1

Frequent Co-Authors

Elsje G. OtteniD· 2 shared Felix RandowiD· 2 shared Katerina NaydenovaiD· 2 shared Keith B. BoyleiD· 2 shared Pierre‐Mehdi HammoudiiD· 2 shared Prathyush PothukuchiiD· 2 shared Akeel Abo AlardiD· 1 shared Alan John WarreniD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Elsje G. OttenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Shigella flexneri evades LPS ubiquitylation through IpaH1.4-mediated degradation of RNF213

Katerina Naydenova, Keith B. Boyle, Claudio Pathe, Prathyush Pothukuchi, Ana Crespillo-Casado, Felix Scharte, Pierre‐Mehdi Hammoudi, Elsje G. Otten, Neal M. Alto, Felix Randow

This study shows Shigella flexneri uses IpaH1.4 to degrade RNF213 and prevent LPS ubiquitylation, evading host antibacterial autophagy.

Nature Structural & Molecular Biology · Apr 9, 2025Peer-reviewedMolecular Biology

Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213

Ana Crespillo-Casado, Prathyush Pothukuchi, Katerina Naydenova, Matthew C. J. Yip, Janet M. Young, Jérôme Boulanger A, Vimisha Dharamdasani, Ceara Harper, Pierre‐Mehdi Hammoudi, Elsje G. Otten, Keith B. Boyle, Mayuri Gogoi, Harmit Singh Malik, Felix Randow

This study identifies how RNF213 recognizes diverse pathogens through enzymatic amplification of cooperative recruitment.

EMBO Reports · Oct 7, 2024Peer-reviewedMolecular Biology

Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, eIF2B

Alisa F. Zyryanova, Félix Weis, Alexandre Faille, Akeel Abo Alard, Ana Crespillo-Casado, Heather P. Harding, Felicity R. Allen, Leopold Parts, Christophe Fromont, Peter M. Fischer, Alan John Warren, David Ron

The paper identifies an ISRIB-binding site in eIF2B using cryo-EM and CRISPR/Cas9, showing its role in regulating translation through an allosteric mechanism.

bioRxiv · Nov 25, 2017 · PreprintMolecular Biology