Félix Weis

Structural basis for guide RNA selection by the RESC1-RESC2 complex

The paper reports the cryo-EM structure of the RESC1-RESC2 complex from Trypanosoma brucei, revealing its role in guide RNA selection through 5-triphosphate binding.

Sequence-independent substrate selection by the eukaryotic wobble base deaminase ADAT2/3 involves multiple protein domains and distortion of the tRNA anticodon loop

This study presents the first structure of a eukaryotic ADAT2/3 deaminase bound to tRNA, revealing sequence-independent substrate selection and a novel gating mechanism for substrate entry.

Elucidation of the viral disassembly switch of tobacco mosaic virus

The paper determines high-resolution cryo-EM structures of tobacco mosaic virus to elucidate the conformational changes in the disassembly switch mechanism.

Structural rearrangement of TFIIS- and TFIIF/TFIIE-like subunits in RNA polymerase I transcription complexes

The paper presents cryo-EM structures of yeast Pol I elongation complexes bound to GMPCPP, revealing structural rearrangements involving TFIIE/TFIIF-like and TFIIS-like subunits.

Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, eIF2B

The paper identifies an ISRIB-binding site in eIF2B using cryo-EM and CRISPR/Cas9, showing its role in regulating translation through an allosteric mechanism.