Christopher D. Putnam

This study uses deep learning and time-resolved imaging to map the genetic network controlling autophagy dynamics, revealing a hierarchical control mechanism and new regulatory aspects.

This study uses antisense oligonucleotides to modulate NLRP3 splicing, reducing its inflammatory activity and systemic inflammation in mouse models.

The paper identifies the cly8 mutation as a temperature-sensitive allele of the ESP1 gene in Saccharomyces cerevisiae through whole genome sequencing and functional analysis.

The paper identifies four categories of mutations based on DNA damage response markers and shows that DDR marker induction is not reliable for predicting genome instability.

This study shows that Mms21 prevents DNA damage-induced genome rearrangements by inhibiting break-induced replication and promoting DNA repair.