Janset Onyuru

This paper shows that TH5487 and SU0268 inhibit NLRP3 activation in FCAS patient PBMCs, overcoming resistance to MCC950 by blocking inflammasome assembly and reducing IL-1β secretion.

This study uses antisense oligonucleotides to modulate NLRP3 splicing, reducing its inflammatory activity and systemic inflammation in mouse models.

This study shows that elevated taurine reduces age-related inflammation by inhibiting the NLRP3 inflammasome and pyroptosis in mice.