Alexandra Fletcher-Jones

SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression

The paper shows that SGIP1 binding to the H9 domain of CB1R promotes axonal surface expression, which regulates presynaptic responsiveness.

Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

This study shows that sustained kainate receptor activation reduces AMPA receptor surface expression and induces hippocampal long-term depression.

The C-terminal Helix 9 motif regulates cannabinoid receptor type 1 trafficking and surface expression

This study identifies the C-terminal Helix 9 domain of CB1R as critical for its axonal surface polarity, stability, and signaling efficiency.