A protective role for B-1 cells and oxidation-specific epitope IgM in lung fibrosis
Jeffrey M. Sturek, Riley T. Hannan, Aditi Upadhye, Eva Otoupalova, Edwin T. Faron, Amr A.E. Atya, Cassidy Thomas, Vernerdean Johnson, Andrew Miller, James C. Garmey, Marie D. Burdick, Thomas Harrison Barker, Alexandra Kadl, Yun Michael Shim, Coleen A. McNamara
This study shows B-1 cells and IgMOSE reduce lung fibrosis by modulating CXCR4 and Id3, with sIgM-/- mice showing increased mortality from bleomycin injury.
bioRxiv · Apr 11, 2024 · PreprintImmunology