Michael P. Hughes

A Spatiotemporal Reconstruction of the C. elegans Pharyngeal Cuticle Reveals a Structure Rich in Phase-Separating Proteins

The paper reconstructs the spatiotemporal gene expression blueprint for C. elegans pharyngeal cuticle construction and identifies phase-separating proteins involved in cuticle remodeling.

The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form

This paper presents the cryoEM structure of hnRNPA2 LCD fibrils, showing structural differences from pathogenic amyloid and how mutations convert it to a pathogenic form.

Low-complexity domains adhere by reversible amyloid-like interactions between kinked β-sheets

The paper reports atomic structures of low-complexity domains showing reversible amyloid-like interactions, identifies hundreds of potential segments in the human proteome, and links them to dynamic intracellular bodies.