Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish
Giulia Allavena, Francesca Rossiello, Aurora Irene Idilli, Marina Mione, Fabrizio d’Adda di Fagagna, Miguel Godinho Ferreira, Bruno Lopes-Bastos
This study shows that telomeric antisense oligonucleotides reduce premature aging in telomerase mutant zebrafish by inhibiting DDR signaling.
bioRxiv · May 23, 2025 · PreprintPathology