Fabrizio d’Adda di Fagagna

This study identifies the glycine-arginine-rich motif of 53BP1 as essential for RNA interactions and phase separation during DNA damage response, showing its role in DNA repair.

The paper shows that dilncRNA, DROSHA, and DICER control DISC by recruiting BMI1 and promoting H2A-K119 ubiquitination at DNA double-strand breaks.

This study shows that TDP-43 and FUS cytoplasmic inclusions impair DNA damage response and repair, and that pharmacological stimulation of DDR can rescue these defects in ALS models.

This study shows that telomeric antisense oligonucleotides reduce premature aging in telomerase mutant zebrafish by inhibiting DDR signaling.

This study shows DROSHA localizes to DNA damage sites and is essential for NHEJ DNA repair.