Ching‐Seng Ang

The paper identifies WEE1, CDK1, and PLK1 as regulators of mRNA export during DNA replication stress, showing their role in preventing R-loop associated mRNA from being exported to the cytoplasm.

This study identifies an autoinhibitory mechanism in the N-terminal extension of AMPKγ3 that regulates basal activity in skeletal muscle, offering a target for T2DM therapies.

The paper compares apoptotic bodies from Sjogren's disease patients and healthy donors, showing they drive B cell and macrophage activation and autoantibody production.

The paper identifies SF3B3 and SF3B5 as a transcription module within the U2 snRNP that regulates Pol II elongation independently of splicing.

This study identifies Menin as a key regulator of oncogenic gene expression in multiple myeloma and shows that Menin inhibitors are effective in myeloma cell lines and models.

The paper determines the cryo-EM structure of LRRC15 and identifies the epitope recognized by the antibody samrotamab, revealing a binding mode that preserves signaling surfaces.

The paper identifies VAR2CSA-specific monoclonal antibodies that synergistically enhance phagocytosis of malaria-infected red blood cells when combined, but none inhibit CSA binding.

This study identifies WEHI-092, a USP9X inhibitor, and shows it arrests cancer cells in metaphase, suggesting USP9X inhibitors could be selective mitotic poisons.

This study presents cryo-EM structures of mycobacterial Ku (mKu) in complex with DNA, revealing its role in NHEJ synapsis and identifying key residues for DNA binding and synaptic assembly.

This study identifies heme biosynthesis as a selective dependency in AML, showing that its inhibition triggers cuproptosis via copper accumulation and reveals synthetic lethal pathways for therapeutic strategies.

This study examines how amniotic fluid extracellular vesicles (AF-EVs) change with gestational age, showing shifts in EV subtypes and protein content that reflect fetal development.

This study characterizes MORC2 phosphorylation's role in DNA compaction and chromatin remodelling, showing it regulates ATP hydrolysis and DNA binding.

The paper identifies cofactors required by different transcription factors and promoters using CRISPR-Cas9 screens and shows that unique cofactor combinations influence transcriptional steps.

The paper uses phosphoproteomics to identify molecular changes in the prefrontal cortex of 5-HTT KO and WT mice after deferiprone treatment, implicating glutamatergic and dopaminergic signaling in its antidepressant-like effects.

The paper identifies proteolytic events in neurons during excitotoxicity using N-terminomics, revealing calpain-mediated cleavage of synaptic proteins and potential therapeutic targets for neuroprotection.