Ciara Frances Pugh

This paper designs a deep learning-generated hASIC1a inhibitor that reduces infarct volume by over 50% in a mouse stroke model.

The paper introduces MAASTY, a copolymer for extracting membrane proteins into native nanodiscs, enabling high-resolution structural analysis with cryo-EM while preserving lipids.

A mouse model with patient-derived DAT mutations reveals dopaminergic dysfunction linked to parkinsonism and psychiatric symptoms through behavioral and neurochemical changes.