Stephen Tomlinson

Age Associated Increase in Microglia Inflammation and Phagocytosis in the Adult Neural Stem Cell Niche

This study shows that aging increases microglia inflammation and phagocytosis in the adult SVZ niche, reducing progenitor proliferation and SVZ neurogenesis.

Luminal Vascular Dysfunction Drives Rapid Blood Brain Barrier Injury in Hyperglycemic Stroke: Key Roles for Luminal Glycocalyx and Complement

This study identifies vascular luminal glycocalyx loss and complement activation as key drivers of BBB injury in hyperglycemic stroke, showing that targeting complement after reperfusion improves outcomes.

Complement C3-targeted gene therapy restricts onset and progression of neurodegeneration in chronic mouse glaucoma

This study shows that targeting complement C3 with gene therapy reduces neurodegeneration in glaucoma by protecting retinal ganglion cells.