Owen P. Leary

A long-read RNA sequencing and polysome profiling framework reveals transposable element-driven transcript diversity and translational rewiring in glioblastoma

This study combines long-read RNA sequencing and polysome profiling to show that transposable elements drive transcript diversity and alter translation in glioblastoma stem cells.

Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.

This study shows that inhibiting HDAC7 alters H3.3 deposition and chromatin structure, leading to DNA replication defects and increased sensitivity to DNA damage in cancer cells.