Author

Mattia D. Pizzagalli

Brown UniversityORCID 0000-0003-0074-1039Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Nikos TapinosiD· 2 shared Owen P. LearyiD· 2 shared Shiven Sasipalli· 2 shared Adrianne Corseri· 1 shared András FiseriD· 1 shared Brian J. HaasiD· 1 shared Daniel Lee· 1 shared David I. KarambiziiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Nikos TapinosORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 21, 2026

A long-read RNA sequencing and polysome profiling framework reveals transposable element-driven transcript diversity and translational rewiring in glioblastoma

Mattia D. Pizzagalli, Shiven Sasipalli, Owen P. Leary…·Nikos Tapinos

This study combines long-read RNA sequencing and polysome profiling to show that transposable elements drive transcript diversity and alter translation in glioblastoma stem cells.

DOI 10.64898/2026.04.18.719388

humanscRNA-seq

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Cancer BiologyJournal of Biological ChemistryPeer-reviewedSep 17, 2025

Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.

Ola Hassan, Mattia D. Pizzagalli, Owen P. Leary…·Nikos Tapinos

This study shows that inhibiting HDAC7 alters H3.3 deposition and chromatin structure, leading to DNA replication defects and increased sensitivity to DNA damage in cancer cells.

5 citations

humanChIP-seq

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