Cancer BiologyJournal of Biological ChemistryPeer-reviewed
Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.
Ola Hassan, Mattia D. Pizzagalli, Owen P. Leary…·Nikos Tapinos
This study shows that inhibiting HDAC7 alters H3.3 deposition and chromatin structure, leading to DNA replication defects and increased sensitivity to DNA damage in cancer cells.