Author

Isabel Strohkendl

The University of Texas at AustinORCID 0000-0002-6290-8685Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aakash SahaiD· 1 shared Alexa L KnightiD· 1 shared Charlotte S Dresser· 1 shared David Ward TayloriD· 1 shared Delisa RamosiD· 1 shared Erin SkeensiD· 1 shared Fatema A. SaifuddiniD· 1 shared George P. LisiiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

Aakash SahaORCID

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2 papers

Recent·Most cited

BiophysicsNature CommunicationsPeer-reviewedOct 9, 2026

A Cryptic Binding Pocket Regulates the Metal-Dependent Activity of Cas9

Mohd Ahsan, Alexa L Knight, Aakash Saha…·Giulia Palermo

This study identifies a cryptic divalent metal binding pocket that regulates Cas9's metal-dependent activity through conformational activation and catalytic efficiency.

3 citations

mechanistic / dynamical modelexperimental assay

𝕏 PostBluesky

Molecular BiologyMolecular CellPeer-reviewedAug 2, 2018

Kinetic basis for DNA target specificity of CRISPR-Cas12a

Isabel Strohkendl, Fatema A. Saifuddin, James R. Rybarski…·Rick Russell

The paper uses quantitative kinetics to analyze DNA target specificity of CRISPR-Cas12a, revealing that R-loop propagation is rate-limiting and mismatches are discriminated during this process.

353 citationstop 1%

CRISPR screenstatistical model

𝕏 PostBluesky