Rick Russell

Structural Basis for Target Discrimination and Activation by Cas13d

This study reveals the structural basis for Cas13d's target discrimination and activation through cryo-EM structures and kinetic analysis of matched and mismatched RNA targets.

Rho ({rho}) Analysis to Dissect RNA Folding and Assembly Pathways

This paper introduces Rho analysis to study RNA folding pathways using mutations and isolated contacts, revealing multiple folding pathways and their modulation.

A high-throughput search for intracellular factors that affect RNA folding identifies E. coli proteins PepA and YagL as RNA chaperones that promote RNA remodeling

The paper identifies E. coli proteins PepA and YagL as RNA chaperones that promote RNA remodeling through in vivo screening and in vitro validation.

Group II Intron-Like Reverse TranscriptasesFunction in Double-Strand Break Repair by Microhomology-Mediated End Joining

The paper identifies a bacterial group II intron-like reverse transcriptase involved in DNA repair via microhomology-mediated end joining.

Template switching by a group II intron reverse transcriptase: biochemical analysis and implications for RNA-seq

The paper analyzes template switching by a group II intron reverse transcriptase, establishing kinetic parameters and identifying conditions for efficient acceptor RNA/DNA capture.

Kinetic basis for DNA target specificity of CRISPR-Cas12a

The paper uses quantitative kinetics to analyze DNA target specificity of CRISPR-Cas12a, revealing that R-loop propagation is rate-limiting and mismatches are discriminated during this process.