Author
The University of Texas at AustinORCID 0000-0001-9960-1161Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
5 papers
Recent·Most cited
James R. Rybarski, Kuang Hu, Alexis M. Hill…·Ilya J. Finkelstein
The paper identifies new CRISPR-associated transposons (CASTs) by analyzing metagenomic databases, revealing novel architectures and systems that co-opt different CRISPR-Cas effectors.
Stephen K. Jones, John A. Hawkins, Nicole V. Johnson…·Ilya J. Finkelstein
The paper profiles cleavage specificity and kinetics of CRISPR nucleases using NucleaSeq and CHAMP, finding engineered Cas9s show improved specificity while wtCas12a has similar specificity to wtCas9 in vitro.
Isabel Strohkendl, Fatema A. Saifuddin, James R. Rybarski…·Rick Russell
The paper uses quantitative kinetics to analyze DNA target specificity of CRISPR-Cas12a, revealing that R-loop propagation is rate-limiting and mismatches are discriminated during this process.
R.A. Greenstein, Stephen K. Jones, Eric C. Spivey…·Bassem Al‐Sady
The paper shows that RNAi-induced heterochromatin spread is stochastic, while a memory element called REIII provides deterministic, high-fidelity spreading in fission yeast.
Eric C. Spivey, Stephen K. Jones, James R. Rybarski…·Ilya J. Finkelstein
This study uses a microfluidic platform to show that fission yeast cells can divide for over 75 generations without showing signs of aging, and their lifespan can be extended by genetic or drug interventions.