Diego F. Joseph

The paper shows that a negatively charged intrinsically disordered region (IDR) in Dicer autoinhibits the enzyme and ensures fidelity of miRNA biogenesis.

This study identifies the DExD/H helicase domain of Dicer as critical for accurate miRNA biogenesis, showing its role in substrate recognition, cleavage, and strand selection in mammals.

This study develops RNA beacons to detect the testis-determining factor (TDF) using in vitro evolved aptamers and shows their binding kinetics and structural interactions.