This study examines how neighborhood conditions relate to epigenetic aging using DNA methylation clocks in a sample of 158 individuals from the Detroit Neighborhood Health Study.

Aging · Mar 14, 2021Peer-reviewedGenomics

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

Cavin K Ward-Caviness, Paul S. de Vries, Kerri L. Wiggins, Jennifer E. Huffman, Lisa R. Yanek, Lawrence F. Bielak, Franco Giulianini, Xiuqing Guo, Marcus Edi Kleber, Tim Kacprowski, Astrid Petersman, George Davey Smith, Fernando Pires Hartwig, Jack Bowden, Gibran Hemani, , Alanna C. Morrison

This paper evaluates the causal effect of fibrinogen on coronary heart disease using Mendelian randomization, finding a small effect with multi-variant methods but not with single variant approaches.

PLoS ONE · May 10, 2019Peer-reviewedGenetics

Evaluating DNA methylation age on the Illuminas methylationEPIC BeadChip

Radhika Dhingra, Lydia Coulter Kwee, David Díaz-Sánchez, Robert B. Devlin, Wayne E. Cascio, Carol Haynes, Elizabeth R. Hauser, Simon Gregory, Svati Shah, William Kraus, Kenneth Olden, Cavin K Ward-Caviness

This study evaluates how DNA methylation age estimation varies across different Illumina methylation arrays, finding that missing probes lead to underestimation of age, but correlations with outcomes remain consistent.

PLoS ONE · Apr 19, 2019Peer-reviewedBioinformatics