Allison E. Aiello

The paper develops time-varying mediation analysis methods for DNA methylation data to study dynamic mediation effects of trauma on PTSD using the Detroit Neighborhood Health Study.

The paper identifies novel CNV loci and dose-dependent gene effects across six psychiatric disorders using genome-wide analysis.

The paper identifies shared and divergent genetic mechanisms across psychiatric disorders using gene-set burden analysis of copy number variants.

This study examines how sociodemographic and lifestyle factors relate to biological aging in younger adults using epigenetic clocks, finding stronger associations with clocks predicting health outcomes than chronological age.

The paper examines how DNA methylation at NFATC1 CpG sites mediates the relationship between different trauma types and PTSD risk in a prospective study.

This study examines how neighborhood conditions relate to epigenetic aging using DNA methylation clocks in a sample of 158 individuals from the Detroit Neighborhood Health Study.

The paper uses machine learning to identify factors predicting prospective risk of post-traumatic stress symptoms, finding that prior PTSS, loneliness, and a specific DNA methylation site are key predictors.

The paper identifies sex-specific changes in monocyte proportions in males with PTSD using methylomic data, showing no such changes in females.

This study identifies ten novel methylation loci associated with PTSD through a meta-analysis of 1,896 cases and controls across ten cohorts, highlighting the AHRR locus and its link to kynurenine levels.

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.