Fernando Pires Hartwig

This study identifies novel genetic loci for BMI, height, and WHRadjBMI in Hispanic/Latino populations and shows the benefits of ancestral diversity in GWAS.

The paper evaluates the WSP model for reducing confounding in epidemiological studies, finding it susceptible to collider bias from assortative mating and attenuating genetic associations for traits like height and education.

This study identifies genetic variants associated with body fat distribution traits in Hispanics/Latinos and finds ancestry-specific associations.

This paper shows that using covariable-adjusted summary associations in two-sample Mendelian randomization can introduce bias, especially when there is residual confounding between the covariable and outcome.

This study investigates the association between breastfeeding and DNA methylation changes in children and adolescents using data from the ALSPAC cohort, finding some consistent methylation sites linked to breastfeeding at ages 7 and 15-17.

This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.

This paper introduces within-family Mendelian randomization methods to reduce biases from family structure and shows they yield different results compared to population-based analyses.

The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.

This paper evaluates the causal effect of fibrinogen on coronary heart disease using Mendelian randomization, finding a small effect with multi-variant methods but not with single variant approaches.

This study identifies over 50 new genetic loci associated with pulmonary function through a multiethnic meta-analysis of 90,715 individuals.

This study identifies 9 new osteoarthritis loci using UK Biobank data and finds causal effects of higher body mass index on osteoarthritis.