Monica Uddin

The paper investigates DNA methylation mediation between PTSD severity and cardiovascular disease risk, identifying six CpGs as potential epigenetic biomarkers.

The paper develops time-varying mediation analysis methods for DNA methylation data to study dynamic mediation effects of trauma on PTSD using the Detroit Neighborhood Health Study.

The paper introduces DEHOGT, a method for detecting differentially expressed genes in RNA-seq data that accounts for overdispersion, and shows it outperforms DESeq and EdgeR on synthetic data and detects more DE genes in microglial cells under stress hormone treatments.

This paper conducts a multi-ancestry GWAS of major depression, identifying 190 loci and 354 genes, with findings showing increased fine-mapping power and bidirectional BMI relationship in European ancestry samples.

The paper develops a heterogeneous mediation analysis method to study DNA methylation's role in PTSD among African Americans, identifying subgroups and mediators linked to PTSD symptoms.

The paper examines how DNA methylation at NFATC1 CpG sites mediates the relationship between different trauma types and PTSD risk in a prospective study.

The paper examines associations between childhood family emotional health, brain grey matter volume, and DNA methylation in saliva, finding mediation effects and enriched biological pathways.

This study examines how neighborhood conditions relate to epigenetic aging using DNA methylation clocks in a sample of 158 individuals from the Detroit Neighborhood Health Study.

The paper uses machine learning to identify factors predicting prospective risk of post-traumatic stress symptoms, finding that prior PTSS, loneliness, and a specific DNA methylation site are key predictors.

RANDOMIZE randomizes metadata to reduce batch effects in DNA methylation microarray data by evenly distributing samples across factors like row, chips, and plates.

The paper performs a meta-analysis of DNA methylation data from military cohorts to identify CpG sites and regions associated with PTSD development.

The paper identifies sex-specific changes in monocyte proportions in males with PTSD using methylomic data, showing no such changes in females.

This study identifies ten novel methylation loci associated with PTSD through a meta-analysis of 1,896 cases and controls across ten cohorts, highlighting the AHRR locus and its link to kynurenine levels.