Gene drive-based population suppression in the malaria vector Anopheles stephensi
Xuejiao Xu, Jingheng Chen, You Wang, Yiran Liu, Yongjie Zhang, Jie Yang, Xiaozhen Yang, Zhengbo He, Jackson Champer
This study develops a gene drive in Anopheles stephensi to suppress malaria populations by targeting the doublesex gene, showing partial success with resistance and improved conversion when combined with a vasa-Cas9 line.
bioRxiv · May 24, 2024 · PreprintGenetics