Xiaozhen Yang

This study evaluates Cas9 fusion proteins in Drosophila to enhance homing gene drive performance by improving HDR and reducing resistance.

This study evaluates CRISPR-based homing gene drives targeting female fertility genes in Drosophila to suppress population growth, finding varying efficiency and fitness costs across targets.

This study identifies APN3 as a functional receptor for Cry4Ba toxin in Aedes aegypti, showing its role in toxin binding and larvicidal activity through genetic knockout experiments.

This study evaluates the efficiency and resistance allele formation of two CRISPR/Cas9-based gene drives in Aedes aegypti, finding one drive achieves super-Mendelian inheritance rates.

This study develops a gene drive in Anopheles stephensi to suppress malaria populations by targeting the doublesex gene, showing partial success with resistance and improved conversion when combined with a vasa-Cas9 line.