Author

Jie Yang

Peking UniversityORCID 0000-0002-5405-0180Unclaimed ORCID profile · follow to get notified of new preprints

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Jie Yang6 papers · East China Normal University

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:Drosophila· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jackson ChamperiD· 4 shared Xuejiao XuiD· 4 shared Jingheng Chen· 3 shared Xiaozhen YangiD· 3 shared Yunchen Xia· 2 shared Andrea Y.N. Tan· 1 shared Jialing FangiD· 1 shared Nan LiangiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersGenetics

Jackson ChamperORCID

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4 papers

Recent·Most cited

The effects of DNA repair factor-Cas9 fusions on homing gene drive performance

Yingke Wu, Xuejiao Xu, Nan Liang, Yunchen Xia, Andrea Y.N. Tan, Jie Yang, Xiaozhen Yang, Jackson Champer

This study evaluates Cas9 fusion proteins in Drosophila to enhance homing gene drive performance by improving HDR and reducing resistance.

bioRxiv · Oct 28, 2026 · PreprintGenetics

A confined gene drive for population modification in the malaria vector Anopheles stephensi

Xuejiao Xu, Yiran Liu, Xihua Jia, Jie Yang, Yunchen Xia, Jingheng Chen, Jackson Champer

The paper develops a confined gene drive system called TARE in Anopheles stephensi to modify mosquito populations, showing it can spread but faces challenges from fitness costs and resistance.

bioRxiv · Apr 3, 2026 · PreprintGenetics

Assessing target genes for homing suppression gene drive

Xuejiao Xu, Jialing Fang, Jingheng Chen, Jie Yang, Xiaozhen Yang, Shibo Hou, Weitang Sun, Jackson Champer

This study evaluates CRISPR-based homing gene drives targeting female fertility genes in Drosophila to suppress population growth, finding varying efficiency and fitness costs across targets.

The EMBO Journal · Feb 6, 2026Peer-reviewedGenetics

Gene drive-based population suppression in the malaria vector Anopheles stephensi

Xuejiao Xu, Jingheng Chen, You Wang, Yiran Liu, Yongjie Zhang, Jie Yang, Xiaozhen Yang, Zhengbo He, Jackson Champer

This study develops a gene drive in Anopheles stephensi to suppress malaria populations by targeting the doublesex gene, showing partial success with resistance and improved conversion when combined with a vasa-Cas9 line.

bioRxiv · May 24, 2024 · PreprintGenetics